The antibody-mediated humoral immune response kills the invading microbes and prevents infections from spreading to other regions of the body.
Immunoglobulins were discovered in 1890 by two immunologists, Emil von Behring and Kitasato Shibasaburo.
Immunoglobulins are glycoproteins that have antibody activity and are found in the blood, lymph, and vascularized tissues of all the jawed vertebrates. They are produced by plasma cells (white blood cells) and play an important role in maintaining the body’s immune system.
Immunoglobulins are attached to the B cell membrane and it has a transmembrane domain in order to be attached to the plasma membrane. Plasma cells are protein-making cells that participate in humoral immune responses against bacteria, viruses, fungi, parasites, cellular antigens, chemicals, and synthetic substances.
There are 5 types of heavy chain constant regions in antibodies (immunoglobulin) and according to these types, they are classified into IgG, IgM, IgA, IgD, and IgE. They are distributed and function differently in the body.
Immunoglobulins in immune system
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| IgA |
